Novel discovery to treat kidney diseases: Reports

New York: A team of researchers reports a novel approach in which three different gene delivery vectors were injected intravenously and directly into the kidneys of mice, rekindling hope to treat kidney diseases with gene therapy.

Before gene therapy can be used to treat renal diseases, delivery of therapeutic genes to the kidney must become much more efficient.

Jeffrey Rubin, Tien Nguyen, Kari Allen, Katayoun Ayasoufi, and Michael Barry from the Mayo Clinic co-authored an article published in the journal Human Gene Therapy.

As the kidney filters out large compounds from the bloodstream, the researchers chose to study the ability to deliver three different sized vectors via an intravenous route: small adeno-associated virus (AAV) vectors (25 nm), larger adenovirus vectors (100 nm) and lentiviral vectors (120 nm).

To bypass this filtering mechanism, they also tested two different direct injection routes into the kidney and found these to be superior to intravenous injections. (IANS)

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