Research Finds Cholesterol Lowering Drugs May Lead To Weaker Muscles, Nervous System

Statin-induced drugs that are prescribed to people with high levels of cholesterol might weaken the patient’s muscles and nervous system, a study has discovered. According to the analysis, that has been published within the journal Cell Metabolism, lipid-lowering medicine reduces the formation of brown adipose tissue that helps to convert sugar and fat into heat. People with brown adipose tissue are higher at control their body temperature within the winter and are less possible to suffer from excess weight or diabetes.

A team of researchers looked into the question of how unhealthy white fat cells, that form the layer of fat underneath our skin, become smart brown fat cells. Having conducted cell culture experiments, they found out that the organic chemistry pathway responsible for producing cholesterol plays a central role during this transformation. They additionally discovered that the key molecule control the transformation is the metabolite geranylgeranyl pyrophosphate.

They additionally studied positron emission pictorial representation scans of 8,500 patients. This allow them to confirm whether or not the person had brown adipose tissue. It absolutely was additionally proverbial whether or not the patients were taking statins. Evaluating the scans shows that 6 per cent of those not taking the medication had brown adipose tissue, but this tissue type was present in only a little over 1 per cent of those who were taking statins.

The researchers conducted a separate clinical study of sixteen individuals to demonstrate that statins reduce the activity of brown adipose tissue.

“We also have to consider that statins are incredibly important as a way to prevent cardiovascular disease. They save millions of lives around the world, and they are prescribed for a very good reason,” said Christian Wolfrum, a researcher.

However, statins also have another negative effect: in high doses, they slightly increase some people’s risk of developing diabetes - as has been shown in other studies.

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