New lethal COVID variant puts world on high alert

NEW DELHI: While several countries are still struggling to tame the novel coronavirus (SARS-CoV-2), the emergence of the new and deadly mutated variant of the "pandemic coronavirus" has put the world once again on high alert as 2021 knocks at the door.

The scientists have scrambled to figure out whether the UK variant titled 'B.1.1.7' is really more adept at human-to-human transmission. They're also wondering how it evolved so fast.

According to the prestigious journal Science, the 'B.1.1.7' variant has acquired 17 mutations all at once — a feat never seen before.

"There's now a frantic push to try and characterise some of these mutations in the lab," Andrew Rambaut, a molecular evolutionary biologist at the University of Edinburgh, was quoted as saying by the magazine on Sunday.

According to the researchers, it seems that this variant (also dubbed as VUI-202012/01) is now starting to dominate over existing versions of the coronavirus.

The worry is: Scientists say that 'B.1.1.7' may already be much more widespread. Other than the UK, it has been detected in the Netherlands, Denmark, Italy and Australia.

"The United Kingdom may just have picked it up first because that country has the most sophisticated SARS-CoV-2 genomic monitoring in the world. Many countries have little or no sequencing," said the report.

According to Rambaut, among the 17 are eight mutations in the gene that encodes the spike protein on the viral surface, two of which are particularly worrisome.

"One, called N501Y, has previously been shown to increase how tightly the protein binds to the ACE2 receptor, its entry point into human cells," he noted.

The other, named 69-70del, leads to the loss of two amino acids in the spike protein and has been found in viruses that eluded the immune response in some immuno-compromised patients. "There's now a frantic push to try and characterise some of these mutations in the lab."

The evolutionary process that led to B.1.1.7 may also occur elsewhere, fear the scientists.

"Whatever enabled the B.1.1.7 lineage to emerge is likely going on in other parts of the world. Will we be able to actually detect it and then follow up on it? That, to me is one of the critical things," said Kristian Andersen, an infectious disease researcher at Scripps Research.

Scientists are becoming more convinced that the new variant of coronavirus is more transmissible.

"Notes from a meeting of the UK's New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG) on December 18 state that the group "has moderate confidence that VUI-202012/01 demonstrates a substantial increase in transmissibility compared to other variants."

That might seem obvious given how quickly the strain appears to be spreading, but it can be hard to exclude other explanations such as a super-spreader event giving the variant a boost - particularly since scientists don't know what might be making the viral strain more infectious.

"Whilst previous variants have successfully emerged in periods of low prevalence without clear evidence of having a selective advantage, the emergence and subsequent dominance of VUI-202012/01 in a period of relatively high prevalence suggests VUI-202012/01 does have a selective advantage over other variants," wrote the scientists who were part of UK's New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG).

The new strain "has demonstrated exponential growth during a period when national lockdown measures were in place," the NERVTAG said in a note. The scientists estimate that the growth rate of the virus is 71 per cent higher than other variants of the virus.

"Four probable reinfections have been identified among 915 subjects with this variant." The NERVTAG scientists, however, wrote that there is currently insufficient data to say what the mechanism of increased transmissibility is or whether the variant is more deadly.

So far, four deaths in around 1,000 cases have been identified and more data was being collected. The World Health Organisation (WHO) has said it is working closely with the UK medical authorities to understand how the new mutant coronavirus variant is likely to affect the course of the pandemic. (IANS)

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